Félix-Antoine Bérubé-Simard

Ph. D.

Researcher

Félix-Antoine Bérubé-Simard holds a bachelor’s degree in microbiology, a master’s degree and a Ph. D. in cell and molecular biology from Université Laval. His doctoral research focused on understanding pulmonary development and the mechanisms associated with emphysema in a mouse model. After his graduate studies, he held a position as a postdoctoral researcher at Université du Québec à Montréal (2014-2019), where he developed an interest in the molecular mechanisms involved in the development of certain rare genetic diseases. He then gathered some experience in laboratory management at the CHU de Québec Research Centre. Félix-Antoine joined Biopterre in November 2020, bolstering our expertise with his 15 years of experience in the field of molecular biology and “omics” technologies, such as metagenomics, transcriptomics and proteomics.

Scientific publications:

  • Silveira, AD., Tav, C., Bérubé-Simard, FA., Fournier, E., Côté, M., Bilodeau, S. (2020, under review) Modulating HSF1 levels impacts expression of the estrogen receptor α and antiestrogen response in breast cancer. Life Sci. Alliance.
  • Vélot, L., Lessard, F., Bérubé-Simard, FA., Tav, C., Neveu, B., Teyssier, V., Boudaoud, I., Dionne, U., Bilodeau, S., Pouliot, F., Bisson, N. (2020, accepted) Proximity-dependent mapping of the Androgen Receptor identifies Kruppel-Like Factor 4 as a functional partner. MCP.
  • Bérubé-Simard, FA., Pilon, N. (2019) Molecular dissection of CHARGE syndrome highlights the vulnerability of neural crest cells to problems with alternative splicing and other transcription-related processes. Transcription 10(1):21-28. doi: 10.1080/21541264.
  • Bélanger, C.*, Bérubé-Simard, FA.*, Leduc, E., Bernas G., Campeau, PM., Lalani, SR., Martin, DM., Bielas, S., Moccia, A., Srivastava, A., Silversides, DW., Pilon, N. (2018) Dysregulation of cotranscriptional alternative splicing underlies CHARGE syndrome. Natl. Acad. Sci. USA. 115(4): E620-E629. doi: 10.1073/pnas.1715378115. (Prix Chercheur étoile FRQS pour Bérubé-Simard, FA.)
  • Farrell, SA., Sodhi, S., Marshall, CR., Guerin, A., Slavotinek, A., Paton, T., Chong, K., Sirkin, WL., Scherer, SW., Bérubé-Simard, FA., Pilon, N. (2017) HLX is a candidate gene for a pattern of anomalies associated with congenital diaphragmatic hernia, short bowel, and asplenia. J. Med. Genet. A. 173(11):3070-3074. doi: 10.1002/ajmg.a.38354.
  • Haffar, T., Bérubé-Simard, FA.Bousette, N. (2015) Impaired fatty acid oxidation as a cause for lipotoxicity in cardiomyocytesBiophys. Res. Commun. 468(1-2):73-8. doi: 10.1016/j.bbrc.2015.10.162.
  • Boucherat, O., Nadeau, V., Bérubé-Simard, FA., Charron, J., Jeannotte, L. (2015) Erratum for Crucial requirement of ERK/MAPK signaling in respiratory tract development. Development 142(21):3801. doi: 10.1242/dev.131821.
  • Boucherat, O., Landry-Truchon, K., Bérubé-Simard, FA., Houde, N., Beuret, L., Lezmi, G., Foulkes, WD., Delacourt, C., Charron, J., Jeannotte, L. (2015) Epithelial inactivation of Yy1 abrogates lung branching morphogenesis. Development 142(17):2981-95. doi: 10.1242/dev.120469.
  • Haffar, T., Bérubé-Simard, FA., Tardif, JC., Bousette, N. (2015) Saturated fatty acids induce endoplasmic reticulum stress in primary cardiomyocytes. Reticul. Stress Dis. 2, 53–66. doi: 10.1515/ersc-2015-0004.
  • Haffar, T., Bérubé-Simard, FA., Bousette, N. (2015) Cardiomyocyte lipotoxicity is mediated by Il-6 and causes down-regulation of PPARs. Biophys. Res. Commun. 459(1):54-9. doi: 10.1016/j.bbrc.2015.02.062.
  • Boucherat, O., Nadeau, V., Bérubé-Simard, FA., Charron, J. and Jeannotte, L. (2014) Critical requirement of ERK/MAPK signaling in respiratory tract development. Development 141(16): 3197-211.
  • Bérubé-Simard, FA., Prudhomme, C., Jeannotte, L. (2014) YY1 Acts as a Transcriptional Activator ofHoxa5 Gene Expression in Mouse OrganogenesisPLOS ONE 9(4): e93989 doi: 10.1371/journal.pone.0093989.
  • Bérubé-Simard, FA., Jeannotte, L. (2014) Hoxa5/Cre transgenic mice: novel tools for regional deletion along the antero-posterior axis. Genesis 52(2):149-56. doi: 10. 1002/dvg.22733.
  • Boucherat, O., Montaron, S., Bérubé-Simard, FA., Aubin, J., Philippidou, P., Wellik, DM., Dasen, JS., Jeannotte, L. (2013) Partial functional redundancy between Hoxa5 and Hoxb5 paralog genes during lung morphogenesis. J. Physiol.-Lung Cell. Mol. Physiol. doi:10.​1152/ajplung.00006.
  • Coulombe, Y., Lemieux, M., Moreau, J., Aubin, J., Joksimovic, M., Bérubé-Simard, FA., Tabariès, S., Boucherat, O., Guillou, F., Larochelle, C., Tuggle, CK., Jeannotte, L. (2010) Multiple promoters and alternative splicing: Hoxa5 transcriptional complexity in the mouse embryo. PLoS ONE 5(5): e10600. doi:10.1371/journal.pone.0010600.
  • Jarinova, O., Hatch, G., Poitras, L., Prudhomme, C., Grzyb, M., Aubin, J., Bérubé-Simard, FA., Jeannotte, L., Ekker, M. (2008) Functional resolution of duplicated hoxb5 genes in teleost. Development 135: 3543-3553.

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